PERITONEAL MESOTHELIOMA
Peritoneal mesothelioma is a cancer of the peritoneum (the lining of the abdominal cavity, approximately 10% of all mesothelioma cases). Currently, surgery and chemotherapy are the standard of care. However, recurrence rates are high. For more information on peritoneal mesothelioma:
- cancer.org/cancer/malignant-mesothelioma.html
- kanker.nl/kankersoorten/mesothelioom/wat-is/mesothelioom-asbestkanker (Dutch)
Phase II study
Six mesothelioma referral centers in five European countries are participating in a pivotal clinical phase II/III study. The study is named DENIM: DENdritic Cell Immunotherapy for Mesothelioma.
The DENIM study is an open-label, randomised, phase II/III study in adults with pleural mesothelioma, to assess the efficacy and anti-tumour activity of MesoPher as maintenance treatment after chemotherapy. Additionally, safety, tolerability, quality of life and immunogenicity of MesoPher will be evaluated.
Amphera is the sponsor of the DENIM study. The DENIM study has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 668769.